Dietary Folate and Vitamin B12 Intake and Cognitive Decline

published in: Pharmacy // Vitamins & Supplements

Dietary Folate and Vitamin B12 Intake and Cognitive Decline
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Dietary Folate and Vitamin B12 Intake and Cognitive Decline Among Community-Dwelling Older Persons. Deficiencies in folate and vitamin B12 have been associated with neurodegenerative disease.

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Dietary Folate and Vitamin B12 Intake and Cognitive Decline Among Community-Dwelling Older Persons
Martha Clare Morris, ScD; Denis A. Evans, MD; Julia L. Bienias, ScD; Christine C. Tangney, PhD; Liesi E. Hebert, ScD; Paul A. Scherr, PhD, ScD; Julie A. Schneider, MD

Background: Deficiencies in folate and vitamin B12 have been associated with neurodegenerative disease. Objective: To examine the association between rates of age-related cognitive change and dietary intakes of folate and vitamin B12. Design: Prospective study performed from 1993 to 2002. Setting: Geographically defined biracial community in Chicago, Ill. Participants: A total of 3718 residents, 65 years and older, who completed 2 to 3 cognitive assessments and a food frequency questionnaire. Main Outcome Measure: Change in cognitive function measured at baseline and 3-year and 6-year followups, using the average z score of 4 tests: the East Boston Tests of immediate and delayed recall, the Mini-Mental State Examination, and the Symbol Digit Modalities Test.

Results: High folate intake was associated with a faster

rate of cognitive decline in mixed models adjusted for multiple risk factors. The rate of cognitive decline among persons in the top fifth of total folate intake (median, 742

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